Meldonium (Mildronate) - 99.00%

$89.00
SKU:
RSA-MELDON-250C28
Meldonium (Mildronate) Capsules
99.00% purity
 

Wikipedia Extract:

Although initial reports suggested meldonium is a non-competitive and non-hydroxylatable analogue of gamma-butyrobetaine; further studies have identified that meldonium is a substrate for gamma-butyrobetaine dioxygenase. X-ray crystallographic and in vitro biochemical studies suggest that meldonium binds to the substrate pocket of γ-butyrobetaine hydroxylase and acts as an alternative substrate, and therefore a competitive inhibitor. Normally, this enzyme's action on its substrates γ-butyrobetaine and 2-oxoglutarate gives, in the presence of the further substrate oxygen, the products L-carnitine, succinate, and carbon dioxide; in the presence of this alternate substrate, the reaction yields malonic acid semialdehyde, formaldehyde (akin to the action of histone demethylases), dimethylamine, and (1-methylimidazolidin-4-yl)acetic acid, "an unexpected product with an additional carbon-carbon bond resulting from N-demethylation coupled to oxidative rearrangement, likely via an unusual radical mechanism." The unusual mechanism is thought likely to involve a Steven's type rearrangement.

Meldonium's inhibition of γ-butyrobetaine hydroxylase gives a half maximal inhibitory concentration (IC50) value of 62 micromolar, which other study authors have described as "potent." Meldonium is an example of an inhibitor that acts as a non-peptidyl substrate mimic.

 
Disclaimer:
 
THIS PRODUCT IS NOT INTENDED TO TREAT, CURE OR DIAGNOSE ANY CONDITION OR DISEASE AND IS INTENDED FOR RESEARCH PURPOSES ONLY. YOU MUST BE AT LEAST 18 YEARS OLD TO PURCHASE THIS PRODUCT.
 
 
THIS PRODUCT HAS NOT BEEN APPROVED FOR HUMAN CONSUMPTION, AND IS FOR SALE ON THE CONDITION THAT IT BE USED FOR RESEARCH PURPOSES ONLY